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U.S. Department of Health and Human Services: Interventions for Health Promotion and Disease Prevention in Native American Populations (R01)

Deadline: May 12, 2017

The Interventions for Health Promotion and Disease Prevention in Native American Populations opportunity seeks to develop, adapt, and test the effectiveness of health promotion and disease prevention interventions in Native American (NA) populations. NA populations are exposed to considerable risk factors that significantly increase their likelihood of chronic disease, substance abuse, mental illness, oral diseases, and HIV-infection. The intervention program should be culturally appropriate and promote the adoption of healthy lifestyles, improve behaviors and social conditions and/or improve environmental conditions related to chronic disease, the consumption of tobacco, alcohol and other drugs, mental illness, oral diseases, and HIV-infection. The intervention program should be designed so that it can be sustained within the entire community with existing resources, and, if successful, disseminated in other Native American communities. The long-term goal is to reduce morbidity and mortality in NA communities.

Specific research objectives are dependent on each participating institute, as follows:

The National Cancer Institute (NCI) is interested in applications that focus on both individual and community interventions relating to primary and secondary (screening) cancer prevention. It is important that researchers consider the context in which people live (place, built environment, etc.) and develop interventions that can improve overall health and result in improved health outcomes as they relate to cancer and cancer survivorship.

The National Institute on Alcoholism and Alcohol Abuse (NIAAA) is interested in prevention interventions that seek to: reduce high risk drinking and alcohol use; promote moderate drinking; postpone onset of drinking among youth; and prevent any alcohol use among pregnant women.

The National Institute on Drug Abuse (NIDA) supports interventions to prevent the onset of drug use, prevent the escalation from drug use to abuse and dependence, and prevent the occurrence of drug-related HIV-risk behavior. Investigators should specifically aim to prevent drug use, drug abuse, and (as relevant) associated co-morbid conditions including, but not limited to, HIV/sexually transmitted infections, child abuse and neglect, injuries, violence, and suicide. Drug abuse prevention research involving these outcomes and/or outcomes reflecting positive adjustment, such as educational achievement, is of interest to NIDA.

The National Institute of Mental Health (NIMH) is interested in applications relevant to preventive interventions in Native American communities in both non-AIDS and AIDS research areas, as follows:

1. Non-AIDS-related research areas:

  • Develop and test empirically informed preventive strategies and implementation approaches to support sustained use of science-based interventions
  • Explore the expansion of science-based interventions that preempt or prevent mental disorders, including suicide
  • Develop culturally appropriate interventions for increasing engagement in mental health services and linkage to care across tribes and geographical regions
  • Use mobile or IT interventions to increase use of evidence-based mental health care for individuals in hard-to-reach remote communities
  • Explore which factors promote resilience and prevent mental disorders in persons at extreme social disadvantage to develop preventive intervention targets

2. AIDS-related research areas:

  • Develop and test interventions to address the prevention, care, and treatment needs for gay men, men who have sex with men (MSM), and other high-risk vulnerable individuals from indigenous communities
  • Develop and test interventions based on the mechanisms that explain HIV-related disparities (e.g., factors like stigma, social/sexual networks, access to and quality of health care, characteristics of health biology)
  • Develop novel multilevel preventive interventions and/or combination biomedical-behavioral approaches to advance HIV prevention and care within those tribal communities most impacted by HIV
  • Explore operations research to focus on barriers, facilitating factors, and outcomes of scaling-up HIV prevention interventions with known efficacy and improve uptake and effectiveness of efficacious interventions, particularly for individuals in hard-to-reach remote communities

The National Institute of Dental and Craniofacial Research (NIDCR) is interested in interventions that focus on dental caries, periodontal disease, oral cancer, and untreated decay. Determinants of oral health exist at individual, family, health care systems, community, organizational/institutional, and policy levels. Reliable access to and use of sustainable preventive and telehealth approaches to oral health care; self-management strategies such as fluoridated toothpaste and water; healthful foods and beverages; and healthy tribal policy are examples. The NIDCR welcomes applications for studies that propose multi-level approaches to improve oral health status and reduce inequalities.

The National Institute on Nursing Research (NINR) is interested in research across the lifespan targeting wellness, management of illness related symptoms, enhancement of palliative and end-of-life care interventions, with an emphasis on individuals, families, communities, underserved, hard-to-reach, and vulnerable populations. Additional information on NINR’s research interests can be found at http://www.ninr.nih.gov/AboutNINR/NINRMissionandStrategicPlan. Specific topics of interest to the NINR include, but are not limited to:

  • Develop innovative behavioral interventions that promote health and prevent illness across the lifespan in diverse and underserved populations (e.g., families with special needs and/or parents or caregivers of persons with chronic illness or developmental disabilities)
  • Elucidate mechanisms underlying health disparities and design interventions to eliminate them with particular attention to geographic and environmental issues, minority status, and persons whose chronic or temporary disabilities limit their access to care
  • Assess behavioral, biological, and genomic mechanisms (e.g., neurohumoral markers for differential responses to behavioral interventions)
  • Improve quality of life by promoting personalized health strategies (e.g., promoting healthy lifestyles, prevention of obesity, prevention of HIV/AIDS transmission)
  • Improve understanding of the complex issues and choices underlying palliative and end-of-life care (e.g., reducing physical and psychological burdens of caregivers) in underserved populations

The National Institute of Environmental Health Sciences (NIEHS) is interested in interventions aimed to reduce the impact of environmental exposures on diseases and disorders among NA populations. In addition to testing impacts of interventions on exposure reduction, applicants also are encouraged to examine impacts on interim preclinical markers of disease when possible. Proposals may include, but are not limited to, projects focused on:

  • Development and testing of culturally-sensitive health promotion strategies and interventions designed to educate tribal leaders and tribal members about historical and emerging environmental hazards
  • Adaptation of proven strategies or existing risk messaging for specific targeted audiences (e.g., for specific age groups, for specific audiences such as health care providers and community health workers, or in formats and media that will be effective in low literacy/health literacy settings)
  • Development and testing of interventions that encourage behavior change to reduce or eliminate exposure
  • Development and testing of existing low cost, sustainable methods that address indoor air pollution or that provide safe alternatives to contaminated drinking water and food and/or remediation of contaminated water, air, and/or soil
  • Testing the impacts of policy-level decisions and interventions that are likely to influence environmental exposure levels and associated health outcomes
  • Development and testing of programs to train and build the capacity of community health workers and local health care professionals to assist tribal members in identifying unhealthy environments and/or environmentally-induced illness and ways to intervene

Award: The total amount available is not published. Application budgets are not limited but need to reflect the actual needs of the proposed project. The project period is up to five years.

Eligibility: Higher education institutions; nonprofits with or without 501(c)(3) IRS status; for-profit organizations; governments; and other organizations, including independent school districts, public housing authorities/Indian housing authorities, Native American tribal organizations (other than federally recognized tribal governments), faith-based or community-based organizations, and regional organizations.

Tribes, communities, and organizations that do not have research experience are strongly encouraged to develop collaborations with research organizations. Involvement of Native researchers and other appropriate professionals also is strongly encouraged.

Link: https://grants.nih.gov/grants/guide/pa-files/PAR-14-260.html

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